NPHLA Intelligence
Clinical Trial Watch
Trials NPHLA follows, synchronised from ClinicalTrials.gov. We flag what matters (new registrations, changes in status and newly posted results) and ignore routine record edits. Every therapy in a trial is investigational.
- DUTCH-WAIST: DUTCH Weight Control in Atrial Fibrillation Study
Rijnstate Hospital. Conditions: Atrial Fibrillation; Obesity; Weight Loss. Investigational — not approved for the use studied.
- A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People With Type 2 Diabetes
Hoffmann-La Roche. Conditions: Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- GATA-3: Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)
Vanderbilt University Medical Center. Conditions: Asthma. Investigational — not approved for the use studied.
- A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- SCALA-TK-CM: A Retrospective Real-World Cohort Study
Novo Nordisk A/S. Conditions: Obesity; Type 2 Diabetes (T2D); Prediabetes; Cardiovascular Disease (CVD); Dyslipidemia; Metabolic Dysfunction-associ…. Investigational — not approved for the use studied.
- DEFINE: A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
Cambridge University Hospitals NHS Foundation Trust. Conditions: Cardiovascular Diseases; Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- EryAdo: Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents
University Hospital, Basel, Switzerland. Conditions: Insulin Resistance; Glucose Tolerance; Body Composition; Gastrointestinal Tolerance; Thrombocyte Aggregation; Blood p…. Investigational — not approved for the use studied.
- STAY-LEAN: Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)
The Cleveland Clinic. Conditions: Obesity. Investigational — not approved for the use studied.
- REDEFINE 1: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- PROTIME: PROTeIn-rich Meals to Control Glucose
German Institute of Human Nutrition. Conditions: Overweight; Obesity; Prediabetes; Type 2 Diabetes. Investigational — not approved for the use studied.
- A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
Antag Therapeutics. Conditions: Adults With Overweight/Obesity and Type 2 Diabetes. Investigational — not approved for the use studied.
- Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Eli Lilly and Company. Conditions: Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- GLOW: GLP-1s to Enhance Lasting Optimal Weight
Wake Forest University Health Sciences. Conditions: Obesity. Investigational — not approved for the use studied.
- TRIUMPH-7: A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Eli Lilly and Company. Conditions: Obesity; Overweight; Chronic Low Back Pain (CLBP). Investigational — not approved for the use studied.
- The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
Eli Lilly and Company. Conditions: Atherosclerotic Cardiovascular Disease (ASCVD); Chronic Kidney Disease (CKD). Investigational — not approved for the use studied.
- INFLAM MOTION: A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
4Moving Biotech. Conditions: Knee Osteoarthritis; Synovitis of Knee. Investigational — not approved for the use studied.
- Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
Mayo Clinic. Conditions: Healthy. Investigational — not approved for the use studied.
- SOLIS-1: A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity
Pfizer. Conditions: Overweight; Obesity; Overweight and/or Obesity; Overweight or Obesity; Overnutrition; Nutrition Disorders; Nutritiona…. Investigational — not approved for the use studied.
- A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- ATTAIN-1: A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
Eli Lilly and Company. Conditions: Obesity; Overweight; Overweight or Obesity. Results posted 2026-08-14. Investigational — not approved for the use studied.
- CER-4-T2D: Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
Brigham and Women's Hospital. Conditions: Cardiovascular Events; Type2 Diabetes; Renal Disease. Investigational — not approved for the use studied.
- A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
Eli Lilly and Company. Conditions: Obesity; Overweight; Type 2 Diabetes. Investigational — not approved for the use studied.
- A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
Eli Lilly and Company. Conditions: Type 2 Diabetes. Investigational — not approved for the use studied.
- TRIUMPH-5: A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
Eli Lilly and Company. Conditions: Obesity. Investigational — not approved for the use studied.
- A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
Eli Lilly and Company. Conditions: Diabetes Mellitus; Insulin Sensitivity. Investigational — not approved for the use studied.
- SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- TRIUMPH-9: A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- Use of Liraglutide in Children Aged 6 to 12 Years With Severe Obesity
University of Sao Paulo General Hospital. Conditions: Severe Obesity; Cardiovascular Function; Liraglutide; Childhood Obesity; Echocardiography; Speckle Tracking. Investigational — not approved for the use studied.
- TRIUMPH-8: A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- TRIUMPH-6: A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
Eli Lilly and Company. Conditions: Obesity. Investigational — not approved for the use studied.
Source: ClinicalTrials.gov, U.S. National Library of Medicine. Trial listings are not recommendations to enrol or prescribe.