NPHLA Intelligence
Clinical Trial Watch
Trials NPHLA follows, synchronised from ClinicalTrials.gov. We flag what matters (new registrations, changes in status and newly posted results) and ignore routine record edits. Every therapy in a trial is investigational.
- A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
Boehringer Ingelheim. Conditions: Healthy; Obesity; Overweight. Investigational — not approved for the use studied.
- Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
Eli Lilly and Company. Conditions: Type 2 Diabetes. Investigational — not approved for the use studied.
- A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity
Boehringer Ingelheim. Conditions: Obesity. Investigational — not approved for the use studied.
- SURPASS-EARLY: A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
Eli Lilly and Company. Conditions: Type 2 Diabetes. Results posted 2026-11-12. Investigational — not approved for the use studied.
- FIPS: Filler Post Market Survey (FIPS)
Croma-Pharma GmbH. Conditions: Wrinkle Reduction. Investigational — not approved for the use studied.
- Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Conditions: Electric Stimulation Therapy; Obesity; Weight Loss; Eating. Investigational — not approved for the use studied.
- SURMOUNT-MMO: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- Deep Brain Stimulation Surgery for Focal Hand Dystonia
National Institute of Neurological Disorders and Stroke (NINDS). Conditions: Dystonia; Focal Dystonia; Musician's Dystonia. Investigational — not approved for the use studied.
- GRABS-0: GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial
Vanderbilt University Medical Center. Conditions: Severe Obesity; Obesity; BMI Greater Than 30. Investigational — not approved for the use studied.
- AMAZE 8: AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Novo Nordisk A/S. Conditions: Obesity; Overweight; Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- TRIUMPH-8: A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- PLATINUM EU: A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)
Merz Aesthetics GmbH. Conditions: Neuromuscular Agents; Peripheral Nervous System Agents; Physiological Effects of Drugs; Acetylcholine Release Inhibit…. Investigational — not approved for the use studied.
- Evaluation of Personalized Nutritional Intervention on Wound Healing of Cutaneous Ulcers in Diabetics
Maimónides Biomedical Research Institute of Córdoba. Conditions: Foot, Diabetic. Investigational — not approved for the use studied.
- A Multidisciplinary Weight Loss Program at AUB-MC
American University of Beirut Medical Center. Conditions: Obesity; Weight Loss. Investigational — not approved for the use studied.
- SOLIS-1: A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity
Pfizer. Conditions: Overweight; Obesity; Overweight and/or Obesity; Overweight or Obesity; Overnutrition; Nutrition Disorders; Nutritiona…. Investigational — not approved for the use studied.
- A Study on the Safety and Clinical Efficacy of Guominkang in the Treatment of Diabetic Kidney Disease
Beijing University of Chinese Medicine. Conditions: Diabetic Kidney Disease (DKD); Type 2 Diabetes; Albuminuria. Investigational — not approved for the use studied.
- A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines
AbbVie. Conditions: Glabellar Lines. Status changed from “Recruiting” on Nov 2, 2026. Investigational — not approved for the use studied.
- Evaluation of Efficacy and Safety of Oral Minoxidil 1 mg in Female Androgenetic Alopecia
Industrial Farmacéutica Cantabria, S.A.. Conditions: Androgenetic Alopecia; Female Pattern Baldness. Investigational — not approved for the use studied.
- A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2 Diabetes Mellitus
Arrowhead Pharmaceuticals. Conditions: Obesity. Status changed from “Recruiting” on Oct 30, 2026. Investigational — not approved for the use studied.
- Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients
University of Miami. Conditions: Crohn Disease. Investigational — not approved for the use studied.
- TRI-MR: An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder
University of Texas Southwestern Medical Center. Conditions: Obesity; Methamphetamine Use Disorder; Cocaine Use Disorder; Stimulant Use Disorders. Investigational — not approved for the use studied.
- A Study to Compare How 2 Different Formulations of Survodutide Are Taken up in the Body When Given by Injection in Healthy Men and Women With and Without Overweight or Obesity
Boehringer Ingelheim. Conditions: Healthy; Obesity. Investigational — not approved for the use studied.
- CONTEMPO: A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AstraZeneca. Conditions: Overweight and Obesity. Investigational — not approved for the use studied.
- PRO-FIT: Effects of a High-protein Diet and Resistance Training on Fat-mass Loss Maintenance
Norwegian University of Science and Technology. Conditions: Obesity (Body Mass Index >30 kg/m2). Investigational — not approved for the use studied.
- Efficacy and Safety of Triple-Combination Cream Plus Microneedling Along With Tranexamic Acid Versus Platelet-Rich Plasma in the Treatment of Moderate-to-Severe Melasma: A Randomized Comparative Study
Bangladesh Medical University. Conditions: Melasma (Facial Melasma). Investigational — not approved for the use studied.
- Switch TZP: Metabolic Effects of Switching From Injectable Semaglutide to Tirzepatide
LMC Diabetes & Endocrinology Ltd.. Conditions: Obesity; Type 2 Diabetes (T2D). Investigational — not approved for the use studied.
- A Study of a Weight Loss Intervention in People With Endometrial Cancer
Memorial Sloan Kettering Cancer Center. Conditions: Endometrial Cancer. Investigational — not approved for the use studied.
- Drug-drug Interaction Study of ZT002 Injection in Overweight and Obese Participants
Beijing QL Biopharmaceutical Co.,Ltd. Conditions: Overweight,Obesity. Investigational — not approved for the use studied.
- Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin. Conditions: Type 1 Diabetes; type1diabetes; Type 1 Diabetes Mellitus. Investigational — not approved for the use studied.
- DECLARED-CT: Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Overweight/Obesity and Impaired Glucose Homeostasis
Lia Bally. Conditions: Menopause; Type 2 Diabetes. Investigational — not approved for the use studied.
- Semaglutide vs Sitagliptin
University Health Network, Toronto. Conditions: Liver Transplant; Complications; Diabetes Mellitus; NASH - Nonalcoholic Steatohepatitis; NAFLD. Investigational — not approved for the use studied.
- A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia
BrightGene Bio-Medical Technology Co., Ltd.. Conditions: Type 2 Diabetes (T2DM). Investigational — not approved for the use studied.
- STOP KNEE-OA: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)
University of Melbourne. Conditions: Obesity; Knee Osteoarthritis; Osteoarthritis, Knee. Investigational — not approved for the use studied.
- ESSENCE: Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
Novo Nordisk A/S. Conditions: Non-alcoholic Steatohepatitis. Investigational — not approved for the use studied.
- A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
Eli Lilly and Company. Conditions: Obesity; Overweight; Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- EV-SAFE-1: Safety of Topical Exosome-Containing Liquid in Healthy Volunteers
West Kazakhstan Marat Ospanov Medical University. Conditions: Skin Irritation; Healthy Volunteers. Investigational — not approved for the use studied.
- The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
Eli Lilly and Company. Conditions: Atherosclerotic Cardiovascular Disease (ASCVD); Chronic Kidney Disease (CKD). Investigational — not approved for the use studied.
- ATTAIN-OA PAIN: A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Eli Lilly and Company. Conditions: Osteoarthritis. Status changed from “Recruiting” on Oct 2, 2026. Investigational — not approved for the use studied.
- RENEW 2: Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
Novo Nordisk A/S. Conditions: Overweight; Obesity; Type 2 Diabetes. Investigational — not approved for the use studied.
- STEP Young: A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- FOCUS: A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
Novo Nordisk A/S. Conditions: Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- KaiNETIC-3: Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
Kailera. Conditions: Obesity. Investigational — not approved for the use studied.
- KaiNETIC-1: Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
Kailera. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- KaiNETIC-2: Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
Kailera. Conditions: Obesity With Diabetes; Overweight With Diabetes. Investigational — not approved for the use studied.
- Study of Patients Being Treated With Anti-obesity Medication
Texas Tech University. Conditions: Obesity and Overweight. Investigational — not approved for the use studied.
- AD: The Impact of Botox on Neuroimmune Interactions in Atopic Dermatitis
Daniel Kaplan. Conditions: Atopic Dermatitis (AD). Investigational — not approved for the use studied.
- A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
Eli Lilly and Company. Conditions: Diabetes Mellitus; Insulin Sensitivity. Investigational — not approved for the use studied.
- The Effect of Oral Semaglutide on Bone Turnover in Patients With T2D: a Randomized Placebo-controlled Clinical Trial
Odense University Hospital. Conditions: Type 2 Diabetes; Osteopenia. Investigational — not approved for the use studied.
- Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital. Conditions: PreDiabetes; Insulin Resistance; Overweight; Obesity. Investigational — not approved for the use studied.
- Post Market Clinical Follow up Evaluating the Performance and Safety of Juläine(TM) on Nasolabial Fold Wrinkles
Nordberg Medical AB. Conditions: Nasolabial Fold. Investigational — not approved for the use studied.
- GLOW: GLP-1s to Enhance Lasting Optimal Weight
Wake Forest University Health Sciences. Conditions: Obesity. Investigational — not approved for the use studied.
- DUTCH-WAIST: DUTCH Weight Control in Atrial Fibrillation Study
Rijnstate Hospital. Conditions: Atrial Fibrillation; Obesity; Weight Loss. Investigational — not approved for the use studied.
- GATA-3: Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)
Vanderbilt University Medical Center. Conditions: Asthma. Investigational — not approved for the use studied.
- Clinical Application of Stem Cell Educator Therapy in Alopecia Areata
Throne Biotechnologies Inc.. Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis. Investigational — not approved for the use studied.
- A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- SCALA-TK-CM: A Retrospective Real-World Cohort Study
Novo Nordisk A/S. Conditions: Obesity; Type 2 Diabetes (T2D); Prediabetes; Cardiovascular Disease (CVD); Dyslipidemia; Metabolic Dysfunction-associ…. Investigational — not approved for the use studied.
- DEFINE: A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
Cambridge University Hospitals NHS Foundation Trust. Conditions: Cardiovascular Diseases; Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- EryAdo: Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents
University Hospital, Basel, Switzerland. Conditions: Insulin Resistance; Glucose Tolerance; Body Composition; Gastrointestinal Tolerance; Thrombocyte Aggregation; Blood p…. Investigational — not approved for the use studied.
- STAY-LEAN: Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)
The Cleveland Clinic. Conditions: Obesity. Investigational — not approved for the use studied.
- REDEFINE 1: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
Source: ClinicalTrials.gov, U.S. National Library of Medicine. Trial listings are not recommendations to enrol or prescribe.