NPHLA Intelligence
Clinical Trial Watch
Trials NPHLA follows, synchronised from ClinicalTrials.gov. We flag what matters (new registrations, changes in status and newly posted results) and ignore routine record edits. Every therapy in a trial is investigational.
- GINEBRA: Glucose-dependent INsulinotropic Polypeptide: Effect on Bone Remodelling and Cell Activity (GINEBRA)
Esbjerg Hospital - University Hospital of Southern Denmark. Conditions: Bone Disease, Metabolic; Diabetes Mellitus, Type 2; Obesity and Obesity-related Medical Conditions. Investigational — not approved for the use studied.
- TOPAZ: Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
yifang zhu. Conditions: Acute Ischemic Stroke (AIS). Investigational — not approved for the use studied.
- LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Boehringer Ingelheim. Conditions: Metabolic Dysfunction Associated Steatohepatitis (MASH); Liver Fibrosis. Investigational — not approved for the use studied.
- DUTCH-WAIST: DUTCH Weight Control in Atrial Fibrillation Study
Rijnstate Hospital. Conditions: Atrial Fibrillation; Obesity; Weight Loss. Investigational — not approved for the use studied.
- A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People With Type 2 Diabetes
Hoffmann-La Roche. Conditions: Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide
Kailera. Conditions: End Stage Renal Disease; Renal Impairment; Obesity; Overweight. Investigational — not approved for the use studied.
- SWIFT: Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer
The Methodist Hospital Research Institute. Conditions: Endometrial Atypical Hyperplasia; Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia; Endometria…. Investigational — not approved for the use studied.
- ACHIEVE-5: A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor
Eli Lilly and Company. Conditions: Type 2 Diabetes. Results posted 2026-10-01. Investigational — not approved for the use studied.
- GATA-3: Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)
Vanderbilt University Medical Center. Conditions: Asthma. Investigational — not approved for the use studied.
- Elecoglipron: A Study to Investigate the Efficacy and Safety of Elecoglipron in Asian Participants With Obesity or Overweight With or Without Type 2 Diabetes Mellitus
AstraZeneca. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
AbbVie. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- REIMAGINE 1: A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise
Novo Nordisk A/S. Conditions: Type 2 Diabetes. Investigational — not approved for the use studied.
- Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema
Novo Nordisk A/S. Conditions: Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- Clinical Application of Stem Cell Educator Therapy in Alopecia Areata
Throne Biotechnologies Inc.. Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis. Investigational — not approved for the use studied.
- Evidence-Based Integrated Protocol to Maximize Hair Follicle Survival in Follicular Unit Extraction (FUE)
Assiut University. Conditions: Androgenetic Alopecia; Cicatricial Alopecia. Investigational — not approved for the use studied.
- Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
Peking University People's Hospital. Conditions: Obesity; Chronic Kidney Disease; Albuminuria. Investigational — not approved for the use studied.
- A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight
Boehringer Ingelheim. Conditions: Obesity. Investigational — not approved for the use studied.
- SCALA-TK-CM: A Retrospective Real-World Cohort Study
Novo Nordisk A/S. Conditions: Obesity; Type 2 Diabetes (T2D); Prediabetes; Cardiovascular Disease (CVD); Dyslipidemia; Metabolic Dysfunction-associ…. Investigational — not approved for the use studied.
- A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
Novo Nordisk A/S. Conditions: Obesity; Type 2 Diabetes. Investigational — not approved for the use studied.
- DEFINE: A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
Cambridge University Hospitals NHS Foundation Trust. Conditions: Cardiovascular Diseases; Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
Boehringer Ingelheim. Conditions: Obesity; Metabolic Dysfunction-associated Steatotic Liver Disease. Investigational — not approved for the use studied.
- TRPTI Metabolic and GLP-1 Pharmacodynamic Study
RDC Clinical Pty Ltd. Conditions: Overweight , Obesity. Investigational — not approved for the use studied.
- EryAdo: Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents
University Hospital, Basel, Switzerland. Conditions: Insulin Resistance; Glucose Tolerance; Body Composition; Gastrointestinal Tolerance; Thrombocyte Aggregation; Blood p…. Investigational — not approved for the use studied.
- STAY-LEAN: Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)
The Cleveland Clinic. Conditions: Obesity. Investigational — not approved for the use studied.
- A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
Novo Nordisk A/S. Conditions: Overweight; Obesity. Investigational — not approved for the use studied.
- WEgovy Real World Assessment of Weight Loss in Korea
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial
Novo Nordisk A/S. Conditions: Diabetes Mellitus, Type 2. Results posted 2023-08-15. Investigational — not approved for the use studied.
- Real-World Patient and Physician Experience With Semaglutide Across Six Emerging Markets
Novo Nordisk A/S. Conditions: Overweight; Obesity. Investigational — not approved for the use studied.
- A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Boehringer Ingelheim. Conditions: Obesity. Investigational — not approved for the use studied.
- REDEFINE 1: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
Novo Nordisk A/S. Conditions: Obesity. Investigational — not approved for the use studied.
- AnteAGE Exosomes and PEARL Multiplier With Microneedling for Facial Skin Quality
Cellese Inc.. Conditions: Skin Aging; Skin Quality. Investigational — not approved for the use studied.
- AnteAGE Biosomes With Radiofrequency Microneedling for Facial Skin Rejuvenation
Cellese Inc.. Conditions: Skin Aging; Facial Rhytides; Skin Tone. Investigational — not approved for the use studied.
- Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity
Zomagen Biosciences Ltd.. Conditions: Obesity. Results posted 2026-09-29. Investigational — not approved for the use studied.
- A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD
Regeneron Pharmaceuticals. Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Investigational — not approved for the use studied.
- TOLEDDO: Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes"
Centre Hospitalier Universitaire Dijon. Conditions: Double Diabetes. Investigational — not approved for the use studied.
- A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity
Pfizer. Conditions: Obesity; Overweight and/or Obesity; Overweight; Treatment Of Obesity. Investigational — not approved for the use studied.
- A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- TELWA: Probiotics in Obese Patients Treated With GLP-1 Receptor Agonists
Nordic Biotic Sp. z o.o.. Conditions: Obesity (Disorder); GLP-1 Receptor Agonist Treatment; Probiotic Intervention; Diabetes Mellitus Type 2. Investigational — not approved for the use studied.
- Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients
Nanjing First Hospital, Nanjing Medical University. Conditions: Obesity / Overweight. Investigational — not approved for the use studied.
- GLYCOTIME: Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes
German Institute of Human Nutrition. Conditions: Prediabetes; Type 2 Diabetes; Obesity &Amp; Overweight. Investigational — not approved for the use studied.
- TIRZE-PAP: Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep Apnoea: A Randomised Comparative Effectiveness Trial
Woolcock Institute of Medical Research. Conditions: Sleep Apnoea; Obesity & Overweight; Sleep Apnea Syndrome, Obstructive. Investigational — not approved for the use studied.
- A Phase 1 Study of VK3019 in Overweight and Obese Adults Without Comorbidities
Viking Therapeutics, Inc.. Conditions: Obese Adults. Investigational — not approved for the use studied.
- SILENCED: Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment
University Hospital, Gentofte, Copenhagen. Conditions: Obesity &Amp; Overweight. Investigational — not approved for the use studied.
- PROTIME: PROTeIn-rich Meals to Control Glucose
German Institute of Human Nutrition. Conditions: Overweight; Obesity; Prediabetes; Type 2 Diabetes. Investigational — not approved for the use studied.
- A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
Antag Therapeutics. Conditions: Adults With Overweight/Obesity and Type 2 Diabetes. Investigational — not approved for the use studied.
- NAION in Non-Diabetic Obese Patients Using GLP-1 Receptor Agonists: A Real-World Study
Istanbul Saglik Bilimleri University. Conditions: Non-arteritic Anterior Ischemic Optic Neuropathy Obesity; Obesity. Investigational — not approved for the use studied.
- A Research Study Looking Into How a High Dose of s.c. Semaglutide Works With Emptying of the Stomach in People With Excess Body Weight
Novo Nordisk A/S. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
Regeneron Pharmaceuticals. Conditions: Overweight or Obesity. Investigational — not approved for the use studied.
- SEMAFORCRANIO: SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years
University Hospital, Angers. Conditions: Craniopharyngioma, Child. Investigational — not approved for the use studied.
- Tirzepatide for Obesity and Meth Use Disorder
University of Texas Southwestern Medical Center. Conditions: Obesity; Methamphetamine Use Disorder. Investigational — not approved for the use studied.
- Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Eli Lilly and Company. Conditions: Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- ATTAIN-NOW: A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Eli Lilly and Company. Conditions: Overweight; Prediabetic State; Prehypertension; Obesity, Abdominal. Investigational — not approved for the use studied.
- Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
National Institute on Alcohol Abuse and Alcoholism (NIAAA). Conditions: Healthy Volunteers; Overweight. Investigational — not approved for the use studied.
- Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
UNC Lineberger Comprehensive Cancer Center. Conditions: Endometrial Cancer; Endometrial Intraepithelial Neoplasia; Grade 1 Endometrial Endometrioid Carcinoma. Investigational — not approved for the use studied.
- GLOW: GLP-1s to Enhance Lasting Optimal Weight
Wake Forest University Health Sciences. Conditions: Obesity. Investigational — not approved for the use studied.
- Treatment for "Asymmetric Crying Facies"
Xiaolei Jin. Conditions: Hemifacial Microsomia; Facial Nerve Paralysis. Investigational — not approved for the use studied.
- Deep Brain Stimulation Surgery for Focal Hand Dystonia
National Institute of Neurological Disorders and Stroke (NINDS). Conditions: Dystonia; Focal Dystonia; Musician's Dystonia. Investigational — not approved for the use studied.
- Body Composition Changes After Initiation of GLP-1 Receptor Agonists in Adults With Obesity or Type 2 Diabetes
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Conditions: Obesity (Disorder); Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study
M.D. Anderson Cancer Center. Conditions: Diabetes; Prostate Cancer. Investigational — not approved for the use studied.
Source: ClinicalTrials.gov, U.S. National Library of Medicine. Trial listings are not recommendations to enrol or prescribe.