NPHLA Intelligence
Clinical Trial Watch
Trials NPHLA follows, synchronised from ClinicalTrials.gov. We flag what matters (new registrations, changes in status and newly posted results) and ignore routine record edits. Every therapy in a trial is investigational.
- A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
Boehringer Ingelheim. Conditions: Healthy; Obesity; Overweight. Investigational — not approved for the use studied.
- Safety and Pharmacokinetics of UI112 Compared With UIC202611 in Healthy Adults
Korea United Pharm. Inc.. Conditions: Bioequivalence; Pharmacokinetics. Investigational — not approved for the use studied.
- A Phase I Study to Evaluate the Food Effect on Ecnoglutide Tablet
Hangzhou Sciwind Biosciences Co., Ltd.. Conditions: Food Effect in Healthy Volunteers; Weight Management. Investigational — not approved for the use studied.
- Effects of a Gut-Active Peptide That Stimulates GLP-1 Release on Appetite and Satiety in Healthy Adults With Overweight
Lembas. Conditions: Appetite and Hunger, Suppression; Satiety and Appetite; Weight Change; Gastrointestinal Symptoms; Body Composition. Investigational — not approved for the use studied.
- A Study of BGM0504 in Participants With Type 2 Diabetes
BrightGene Bio-Medical Technology Co., Ltd.. Conditions: Type 2 Diabetes Mellitus (T2DM). Status changed from “Active, not recruiting” on Nov 13, 2026. Investigational — not approved for the use studied.
- Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
Eli Lilly and Company. Conditions: Type 2 Diabetes. Investigational — not approved for the use studied.
- AMBITION 3: AMBITION 3: A Research Study Investigating How Well Zenagamtide at Higher Dose Levels Lowers Blood Sugar and Body Weight Compared to Semaglutide in People With Type 2 Diabetes Treated With Metformin, SGLT2i, or Both
Novo Nordisk A/S. Conditions: Type 2 Diabetes. Investigational — not approved for the use studied.
- AMBITION4: A Research Study Investigating How Well Zenagamtide at Lower Dose Levels Lowers Blood Sugar and Body Weight Compared to Semaglutide at Lower Dose Levels in People With Type 2 Diabetes Treated With Metformin, Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i), or Both
Novo Nordisk A/S. Conditions: Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- GLP-1 Receptor Agonists in the Surgical Patient: Prevalence, Epidemiology, and Pulmonary Complications
University of Virginia. Conditions: GLP-1 Receptor Agonist Treatment. Investigational — not approved for the use studied.
- SURMOUNT-1: Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
Hudson Biotech. Conditions: Obesity; Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities. Investigational — not approved for the use studied.
- A Retrospective Study to Assess Patient-Reported Treatment Experience With Over-the-Counter Analgesic Products
HALEON. Conditions: Pain. Investigational — not approved for the use studied.
- PRESERVE GLP-1: Lifestyle Strategies to Preserve Muscle and Reduce Cardiovascular Risk in Adults With Obesity Using GLP-1 Receptor Agonists
University of Florida. Conditions: Obesity & Overweight. Investigational — not approved for the use studied.
- COURAGE: A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation
Regeneron Pharmaceuticals. Conditions: Obesity. Investigational — not approved for the use studied.
- Changes in Body Composition and Muscle Composition After GLP-1 Receptor Agonist Therapy in Patients With Obesity
Ulsan University Hospital. Conditions: Obesity & Overweight. Investigational — not approved for the use studied.
- A Two-part Study of Lembas Edge Evaluating Tolerability and Postprandial Glycemic Control
Lembas. Conditions: Postprandial Glycemic Control; Prediabetic Overweight and Obese Adults. Investigational — not approved for the use studied.
- The Purpose of This Study is to Learn About the Safety and Effectiveness of Berobenatide in Women With Urine Leakage and With Obesity or Overweight
Pfizer. Conditions: Urinary Incontinence, Stress; Overweight and/or Obesity. Investigational — not approved for the use studied.
- A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity
Boehringer Ingelheim. Conditions: Obesity. Investigational — not approved for the use studied.
- Rutazyme Lemon Fermented Product Capsules for Metabolic Function in Adults With Obesity
National Taiwan Sport University. Conditions: Obesity; Metabolic Syndrome. Investigational — not approved for the use studied.
- PoLiFat: Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects With Type 2 Diabetes
Federico II University. Conditions: Diabetes Mellitus Type 2. Investigational — not approved for the use studied.
- Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy
Vanderbilt University Medical Center. Conditions: Duchenne Muscular Dystrophy (DMD). Investigational — not approved for the use studied.
- PORTIONS_V_RCT: Comprehensive Intervention for Changing Eating Habits Through Portion Control
Clinica Universidad de Navarra, Universidad de Navarra. Conditions: Lifestyle Intervention; Weight Management; Behaviour Change; Portion Size. Investigational — not approved for the use studied.
- RESIST-EXHALE: Breath Acetone During Tirzepatide Treatment and Resistance Training in Adults With Obesity
Technical University of Munich. Conditions: Obesity (Disorder). Investigational — not approved for the use studied.
- SURPASS-EARLY: A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
Eli Lilly and Company. Conditions: Type 2 Diabetes. Results posted 2026-11-12. Investigational — not approved for the use studied.
- RESIST-EXPLORE: Molecular and Microbiome Changes During Tirzepatide Treatment and Resistance Training in Obesity
Technical University of Munich. Conditions: Obesity (BMI Equal to or >30). Investigational — not approved for the use studied.
- FIPS: Filler Post Market Survey (FIPS)
Croma-Pharma GmbH. Conditions: Wrinkle Reduction. Investigational — not approved for the use studied.
- PREPARE CHILD: PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarhus
Ulla Kampmann Opstrup. Conditions: Overweight and Obesity; Weight Loss; Pregnancy Related; Child Nutrition Sciences; Body Composition. Investigational — not approved for the use studied.
- Study to Evaluate Xtressé Gummy Supplement in Women With Thinning Hair
Restore Biologics Holdings, Inc. dba Xtressé. Conditions: Androgenetic Alopecia. Investigational — not approved for the use studied.
- ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management
Shanghai Zhongshan Hospital. Conditions: Obesity; Weight Control. Investigational — not approved for the use studied.
- Multimodal Liquid-Biopsy Omics Biomarkers of Treatment Response in Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University. Conditions: Lung Cancer Non-small Cell; Colorectal Cancer; Stomach Cancer; Hepatocellular Carcinoma; Breast Cancer. Status changed from “Not yet recruiting” on Nov 12, 2026. Investigational — not approved for the use studied.
- A Study to Evaluate ALN-2232 in Participants With Obesity
Alnylam Pharmaceuticals. Conditions: Obesity. Investigational — not approved for the use studied.
- Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Conditions: Electric Stimulation Therapy; Obesity; Weight Loss; Eating. Investigational — not approved for the use studied.
- SURMOUNT-MMO: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- TOPAZ: Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
yifang zhu. Conditions: Acute Ischemic Stroke (AIS). Status changed from “Not yet recruiting” on Nov 12, 2026. Investigational — not approved for the use studied.
- A Study to Compare Different Doses of Tifeglipron (RO7795081) With Placebo or Semaglutide in People With Type 2 Diabetes
Hoffmann-La Roche. Conditions: Type 2 Diabetes Mellitus. Status changed from “Active, not recruiting” on Nov 12, 2026. Investigational — not approved for the use studied.
- GZBF: Effect of Retatrutide Versus Placebo in Participants Who Have Obesity or Are Overweight
Hudson Biotech. Conditions: Obesity. Investigational — not approved for the use studied.
- Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
National Institute on Alcohol Abuse and Alcoholism (NIAAA). Conditions: Healthy Volunteers; Overweight. Investigational — not approved for the use studied.
- ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
Boehringer Ingelheim. Conditions: Obesity; Metabolic Dysfunction-associated Steatotic Liver Disease. Investigational — not approved for the use studied.
- A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Boehringer Ingelheim. Conditions: Obesity. Investigational — not approved for the use studied.
- Deep Brain Stimulation Surgery for Focal Hand Dystonia
National Institute of Neurological Disorders and Stroke (NINDS). Conditions: Dystonia; Focal Dystonia; Musician's Dystonia. Investigational — not approved for the use studied.
- The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes
Imperial College London. Conditions: Steroid-Induced Diabetes; Steroid Induced Hyperglycemia. Investigational — not approved for the use studied.
- Optimum 2: A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
Gan & Lee Pharmaceuticals.. Conditions: Type 2 Diabetes Mellitus (T2DM). Investigational — not approved for the use studied.
- PAOLA: A Study of NT 201 Doses in the Treatment of Platysma Prominence
Merz Aesthetics GmbH. Conditions: Platysma Prominence. Results posted 2026-11-10. Investigational — not approved for the use studied.
- GZR18-BWM-303: Extension Study of the Phase 3 Clinical Study of GZR18 Injection for Weight Loss
Gan & Lee Pharmaceuticals.. Conditions: Overweight or Obesity. Investigational — not approved for the use studied.
- A Study to Evaluate the Safety and Efficacy of Ecnoglutide Tablets in Chinese Participants With Overweight or Obesity
Hangzhou Sciwind Biosciences Co., Ltd.. Conditions: Overweight , Obesity; Weight Management. Investigational — not approved for the use studied.
- CLEAR-GLP1: 24-hour Clear Liquid Diet vs. Standard Fasting for Upper Gastrointestinal Endoscopy in Patients Taking Agonists of the GLP-1 Receptor
Portuguese Oncology Institute, Coimbra. Conditions: Retained Gastric Content; Delayed Gastric Emptying; Obesity; Type 2 Diabetes Mellitus (DM). Investigational — not approved for the use studied.
- Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe Hidradenitis Suppurativa Living With Overweight or Obesity
Regeneron Pharmaceuticals. Conditions: Hidradenitis Suppurativa. Investigational — not approved for the use studied.
- IMPACT: The Impact of Incretins on Fat-free Mass, Muscle Strength and Functional Capacity
Radboud University Medical Center. Conditions: Obesity & Overweight. Investigational — not approved for the use studied.
- Preoperative Weight Loss for Open Abdominal Wall Reconstruction
Benjamin T. Miller. Conditions: Abdominal Wall Hernia. Investigational — not approved for the use studied.
- GRABS-0: GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial
Vanderbilt University Medical Center. Conditions: Severe Obesity; Obesity; BMI Greater Than 30. Investigational — not approved for the use studied.
- RESIST-MIND: Functional, Cognitive, and Behavioral Correlates of Resistance Training During Tirzepatide-Induced Weight Loss
Technical University of Munich. Conditions: Obesity (Disorder). Investigational — not approved for the use studied.
- AMAZE 8: AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Novo Nordisk A/S. Conditions: Obesity; Overweight; Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- TRIUMPH-8: A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Eli Lilly and Company. Conditions: Obesity; Overweight. Investigational — not approved for the use studied.
- BioM: Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine
Nordlandssykehuset HF. Conditions: Migraine. Status changed from “Not yet recruiting” on Nov 10, 2026. Investigational — not approved for the use studied.
- CITTE: Comparing Injection Treatments for Tennis Elbow
Wrightington, Wigan and Leigh NHS Foundation Trust. Conditions: Tennis Elbow; Lateral Epicondylitis; Elbows Tendonitis. Investigational — not approved for the use studied.
- PRE-CARE-DIET: Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols
University of Parma. Conditions: Individual Variability in (Poly)Phenol Metabolism; Cardiometabolic Health; Personalized Dietary Intervention; Obesity. Investigational — not approved for the use studied.
- Pathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide.
Institute of Liver and Biliary Sciences, India. Conditions: Chronic Kidney Diseases; MAFLD. Investigational — not approved for the use studied.
- GLP1: Semaglutide in Youth With Autism Spectrum Disorder
Children's Hospital Medical Center, Cincinnati. Conditions: Autism Spectrum Disorder; Obesity. Investigational — not approved for the use studied.
- COMPACT: Exercise and Protein to Reduce Muscle Loss During GLP-1-Based Treatment in Type 2 Diabetes
German Diabetes Center. Conditions: Type 2 Diabetes (T2DM); Obesity & Overweight; Sarcopenia. Investigational — not approved for the use studied.
- SERINITY: A Single Ascending Dose and Multiple Ascending Dose Trial to Assess the Dose, the Efficacy and Oro-sensitivity of Two Modified Linoleic Acids NKS-3 and NKS-5
EktaH. Conditions: Obesity & Overweight; Overweight (BMI > 30). Investigational — not approved for the use studied.
- Efficacy, Safety and Cardiovascular Protection of Mazdutide in Type 1 Diabetes
Peking University People's Hospital. Conditions: Type 1 Diabetes. Investigational — not approved for the use studied.
Source: ClinicalTrials.gov, U.S. National Library of Medicine. Trial listings are not recommendations to enrol or prescribe.