NPHLA Intelligence
Clinical Trial Watch
Trials NPHLA follows, synchronised from ClinicalTrials.gov. We flag what matters (new registrations, changes in status and newly posted results) and ignore routine record edits. Every therapy in a trial is investigational.
- A Study of BGM0504 in Participants With Type 2 Diabetes
BrightGene Bio-Medical Technology Co., Ltd.. Conditions: Type 2 Diabetes Mellitus (T2DM). Status changed from “Active, not recruiting” on Nov 13, 2026. Investigational — not approved for the use studied.
- GLP-1 Receptor Agonists in the Surgical Patient: Prevalence, Epidemiology, and Pulmonary Complications
University of Virginia. Conditions: GLP-1 Receptor Agonist Treatment. Investigational — not approved for the use studied.
- COURAGE: A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation
Regeneron Pharmaceuticals. Conditions: Obesity. Investigational — not approved for the use studied.
- Rutazyme Lemon Fermented Product Capsules for Metabolic Function in Adults With Obesity
National Taiwan Sport University. Conditions: Obesity; Metabolic Syndrome. Investigational — not approved for the use studied.
- PoLiFat: Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects With Type 2 Diabetes
Federico II University. Conditions: Diabetes Mellitus Type 2. Investigational — not approved for the use studied.
- A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Boehringer Ingelheim. Conditions: Obesity. Investigational — not approved for the use studied.
- Optimum 2: A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
Gan & Lee Pharmaceuticals.. Conditions: Type 2 Diabetes Mellitus (T2DM). Investigational — not approved for the use studied.
- PAOLA: A Study of NT 201 Doses in the Treatment of Platysma Prominence
Merz Aesthetics GmbH. Conditions: Platysma Prominence. Results posted 2026-11-10. Investigational — not approved for the use studied.
- GZR18-BWM-303: Extension Study of the Phase 3 Clinical Study of GZR18 Injection for Weight Loss
Gan & Lee Pharmaceuticals.. Conditions: Overweight or Obesity. Investigational — not approved for the use studied.
- SERINITY: A Single Ascending Dose and Multiple Ascending Dose Trial to Assess the Dose, the Efficacy and Oro-sensitivity of Two Modified Linoleic Acids NKS-3 and NKS-5
EktaH. Conditions: Obesity & Overweight; Overweight (BMI > 30). Investigational — not approved for the use studied.
- A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
Eli Lilly and Company. Conditions: Overweight or Obesity; CKD; Type 2 Diabetes. Results posted 2026-11-09. Investigational — not approved for the use studied.
- QUEST: Lifestyle Counseling and Medication for Adolescent Weight Management
University of Minnesota. Conditions: Obesity, Childhood. Results posted 2026-11-06. Investigational — not approved for the use studied.
- T2DM: UBT251 Injection Phase II (Type 2 Diabetes Mellitus) Study
The United Bio-Technology (Hengqin) Co., Ltd.. Conditions: Type 2 Diabetes Mellitus (T2DM). Investigational — not approved for the use studied.
- RHA®4 for Midface Volume Deficiency
Teoxane SA. Conditions: Cheek Augmentation; Correction of Age-related Midface Contour Deficiencies. Results posted 2025-03-18. Investigational — not approved for the use studied.
- Exosomes for Striae Distensae
Tanta University. Conditions: Striae Distensae. Investigational — not approved for the use studied.
- The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide
American University of Beirut Medical Center. Conditions: Obesity; Weight Loss. Investigational — not approved for the use studied.
- VESPER-3: A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight
Pfizer. Conditions: Obesity; Overweight or Obesity. Investigational — not approved for the use studied.
- GALACTUS: Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial)
Instituto Mexicano del Seguro Social. Conditions: Acute Myocardial Infarction With ST Elevation. Investigational — not approved for the use studied.
- The Effects of Glucagon on Hepatic Metabolism
Adrian Vella. Conditions: Obesity; Type2diabetes; NAFLD. Results posted 2026-10-14. Investigational — not approved for the use studied.
- RICHER: A Non-Interventional PMCF Study Evaluating Croma Revitalis for the Correction of Fine Lines
Croma-Pharma GmbH. Conditions: Lateral Canthal Lines (LCL); Perioral Rhytids. Investigational — not approved for the use studied.
- Pilot Study of Combination Treatment With Subcision, Human Adipose Tissue-Derived Exosomes and Powdered Polydioxanone for Atrophic Acne Scars
COSMEDICIAN AP SDN BHD. Conditions: Atrophic Acne Scars. Investigational — not approved for the use studied.
- The Effect of Liraglutide on Body Weight, Body Composition, Ectopic Lipid Accumulation and Insulin Sensitivity in Subjects With Overweight or Obesity Without Diabetes
Medical University of Bialystok. Conditions: Obesity & Overweight. Investigational — not approved for the use studied.
- Constraint-induced Movement Therapy Versus Task-oriented Training On Upper Extremity Function Post-Botox Injection in Stroke Patients
Cairo University. Conditions: Constraint Induced Movement Therapy; Task Oriented Training; Botox Injection; Upper Extremity Function; Stroke. Investigational — not approved for the use studied.
- STEP HFpEF DM: Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes
Novo Nordisk A/S. Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF) and Diabetes Mellitus, Type 2. Results posted 2026-11-02. Investigational — not approved for the use studied.
- A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
Pfizer. Conditions: Obesity and Obesity-related Medical Conditions. Investigational — not approved for the use studied.
- Comparative Study of The Efficacy and Safety of Subcision Combined With Injection of Exosomes Versus Subcision Alone in Treatment of Atrophic Post- Acne Scars.
Tanta University. Conditions: Acne Scars - Atrophic. Investigational — not approved for the use studied.
- Nutritional Therapy to Incretin-based Anti-obesity Medications in the Management of Gastrointestinal Adverse Events
Ariel University. Conditions: Obesity; Drug. Investigational — not approved for the use studied.
- A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
Adrian Vella. Conditions: Healthy. Results posted 2026-10-28. Investigational — not approved for the use studied.
- Male Intimate Harmonization: Efficacy, Satisfaction, and Safety
Antony Barbosa Institute. Conditions: Male Intimate Harmonization Methods. Investigational — not approved for the use studied.
- Comparative Analysis of Intralesional Platelet-Rich Plasma, NPH Insulin, and Vitamin C- A New Horizon and Future Hope for Linear Atrophic Scar Management
Aya Ashraf Fouda. Conditions: Linear Atrophic Scars. Investigational — not approved for the use studied.
- TIRZ-DOSE-NL: Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Radboud University Medical Center. Conditions: Overweight , Obesity; Obesity (Disorder). Investigational — not approved for the use studied.
- Efficacy and Safety of CosmeRNA-ARI Anti Hair Loss Tonic in Adults With Androgenetic Alopecia
BIONEER Corporation. Conditions: Androgenetic Alopecia. Investigational — not approved for the use studied.
- NEUROQUIET: Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Ukrainian Society of Regional Anesthesia and Pain Therapy. Conditions: Chronic Pain Due to Injury; Neuroma of Lower Limb; Neural Injury; Neuroma of Upper Limb; Combat Related Symptoms. Investigational — not approved for the use studied.
- Study of BMF-650 in Otherwise Healthy Overweight or Obese Adult Participants
Biomea Fusion Inc.. Conditions: Obesity. Investigational — not approved for the use studied.
- A Study in Healthy People to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
Boehringer Ingelheim. Conditions: Healthy. Investigational — not approved for the use studied.
- Effects of Semaglutide in HIV-Associated Lipohypertrophy
Case Western Reserve University. Conditions: HIV/AIDS; Lipohypertrophy; Obesity. Results posted 2026-02-17. Investigational — not approved for the use studied.
- RESOLVE-2: Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2)
Rezera (formerly NodThera Limited). Conditions: Obesity. Investigational — not approved for the use studied.
- NATRIURETIC: Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial
University Health Network, Toronto. Conditions: Type 2 Diabetes Mellitus. Investigational — not approved for the use studied.
- BARI-STEP: Semaglutide 2.4 mg in Patients With Poor Weight-loss
University College, London. Conditions: Obesity; Diabetes; Metabolic Syndrome. Results posted 2026-10-26. Investigational — not approved for the use studied.
- Liragest: Liraglutide in the Prevention of Type 2 Diabetes After Gestational Diabetes
Turku University Hospital. Conditions: Gestational Diabetes. Investigational — not approved for the use studied.
- INFLAM MOTION: A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
4Moving Biotech. Conditions: Knee Osteoarthritis; Synovitis of Knee. Status changed from “Active, not recruiting” on Oct 23, 2026. Investigational — not approved for the use studied.
- MINOX: Treatment of Androgenetic Alopecia in Men for 24 Weeks
Eurofarma Laboratorios S.A.. Conditions: Alopecia. Investigational — not approved for the use studied.
- A Controlled Study to Evaluate the Effects of a Supplement on Weight Loss, Blood Sugar, and Appetite Suppression
Evolv. Conditions: Overweight; Obesity; Blood Sugar Regulation; Appetite Suppression; Weight Management. Investigational — not approved for the use studied.
- SILENCED: Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment
University Hospital, Gentofte, Copenhagen. Conditions: Obesity &Amp; Overweight. Investigational — not approved for the use studied.
- Pembro/IORT: Effects of MK-3475 (Pembrolizumab) on the Breast Tumor Microenvironment in Triple Negative Breast Cancer
Columbia University. Conditions: Triple Negative Breast Cancer. Investigational — not approved for the use studied.
- A Study of the Safety, Tolerability, and Efficacy of Topical SM04554 Solution in Male Subjects With Androgenetic Alopecia (AGA)
Biosplice Therapeutics, Inc.. Conditions: Androgenetic Alopecia. Results posted 2026-10-01. Investigational — not approved for the use studied.
- Safety, Pharmacokinetics and Efficacy of PP405 in Adults With AGA
Pelage Pharmaceuticals, Inc.. Conditions: Androgenetic Alopecia. Results posted 2026-09-22. Investigational — not approved for the use studied.
- A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
Novo Nordisk A/S. Conditions: Type 2 Diabetes. Investigational — not approved for the use studied.
- TIMEX: Hedonic and Homeostatic Appetite Control in Obesity and Type 2 Diabetes in the Context of Meal and Exercise Timing
Steno Diabetes Center Copenhagen. Conditions: Overweight and Obesity; Type 2 Diabetes. Investigational — not approved for the use studied.
- A First in Human (FIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DR10624
Zhejiang Doer Biologics Co., Ltd.. Conditions: Healthy, Obesity, Metabolically. Results posted 2026-10-19. Investigational — not approved for the use studied.
- REIMAGINE 5: A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
Novo Nordisk A/S. Conditions: Diabetes Mellitus, Type 2. Investigational — not approved for the use studied.
- ACHIEVE-2: A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin
Eli Lilly and Company. Conditions: Type 2 Diabetes. Results posted 2026-10-16. Investigational — not approved for the use studied.
- GIST: Graded Insulin Suppression Test P&F
Columbia University. Conditions: Insulin Resistance; Hyperinsulinemia; Obesity; Healthy. Investigational — not approved for the use studied.
- Effect of Food Temperature and Diet Composition on Satiety, Satiety Hormones, Chewing Time and Neuronal Activity
Khyber Medical University Peshawar. Conditions: Obesity, Overweight. Investigational — not approved for the use studied.
- Aleniglipron Phase 2 Body Composition Study
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics. Conditions: Obesity, Overweight, or Chronic Weight Management. Investigational — not approved for the use studied.
- ELITE: ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy Aging
Sheba Medical Center. Conditions: Healthy Aging. Investigational — not approved for the use studied.
- A Study of BGM0504 in Participants With Obesity
BrightGene Bio-Medical Technology Co., Ltd.. Conditions: Obesity. Investigational — not approved for the use studied.
- SEMA-CKM: Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes
LMC Diabetes & Endocrinology Ltd.. Conditions: Diabetes (DM); Type 2 Diabetes; Obesity (Disorder). Investigational — not approved for the use studied.
- Fractional CO₂ Laser Combined With Topical Plant-Derived Exosomes Versus Non-Cross-Linked Hyaluronic Acid for Atrophic Acne Scars
October 6 University. Conditions: Atrophic Acne Scar. Investigational — not approved for the use studied.
- ProSem: Probiotics in Obese Patients Treated With Semaglutide
Nordic Biotic Sp. z o.o.. Conditions: Obesity (Disorder); GLP-1 Receptor Agonist Treatment; Probiotic Intervention; Diabetes Mellitus Type 2. Investigational — not approved for the use studied.
Source: ClinicalTrials.gov, U.S. National Library of Medicine. Trial listings are not recommendations to enrol or prescribe.